How does Bevacizumab work

Different from chemotherapy that directly attack cancer cells, Bevacizumab functions by blocking blood supply to a tumor, so as to inhibit its growth.

Vascular endothelial growth factor (VEGF) promotes angiogenesis by inducing proliferation of endothelial cells. With overexpression of VEGFs in diverse tumors, Bevacizumab blocks combination of free VEGFs and relevant receptors to inhibit neoplastic neovascularization. As tumor gets diminishing support in nutrition, it will be restrained from growth eventually.

Key to anti-angiogenesis therapy - continuous inhibition of VEGF pathways

Crucial factor for regulating angiogenesis - interaction of VEGC ligands and receptors

Bevacizumab targets VEGF and sustainably inhibits tumor growth

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